Design, Optimization, in vitro and in vivo Evaluation of Flurbiprofen Loaded Solid Lipid Nanoparticles (SLNs) Topical Gel

Abstract: Background: The aim of present study was to carry out the formulation design and evaluation Solid Lipid Nanoparticles (SLNs) loaded topical gel Flurbiprofen. Materials Methods: Flurbiprofen solid lipid nanoparticles were formulated using Glyceryl monostearate (GMS) as matrix by solvent evaporation method followed probe sonication. A 32 full factorial utilized optimize SLNs. Drug: ratio sonication time chosen independent variables. Particle size, entrapment efficiency (%) PDI dependent optimized SLNs screened for pH, spredability, drug content, viscosity, release study, TEM analysis in vivo skin irritation studies. Results: SLNs-gel had particle size 369.8 nm, 70.66% 0.241. zeta potential found be -33.4 mV resembling better stability. Drug showed sustained pattern with maximum 96.78% up 10 hr following Highuchi kinetics mechanism. revealed that nano scale range. In on wister rats proved didn’t any signs irritation. Conclusion: Based obtained results, concluded based can promising delivery approach. Keywords: SLNs, DoE, Flurbiprofen, Zeta Potential, vitro release.